Clostridium Difficile Infection


Clostridium difficile


10 days

Non severe

ORAL Metronidazole 400mg 8 hourly

Severe/Recurrence or not improving after 5 days

ORAL Vancomycin 125mg 6 hourly

(In swallowing difficulties – injection licensed for oral administration)

If ileus or hypotension:

+ IV Metronidazole 500mg 8 hourly


Severe if:

  • Colonic dilation > 6cm
  • White cell count > 15 x 109/L
  • Creatinine > 1.5 x baseline

Refer to FirstPort for full guidance on Management and Treatment of C.Diff