Clostridium Difficile

Clostridium difficile

DH

 

PHE

 

Stop unnecessary antibiotics, PPIs and antiperilstaltic agents.

70% respond to MTZ in 5 days; 92% in 14 days.

If severe symptoms or signs (below) should treat with oral vancomycin, review progress closely and/or consider hospital referral.

Definition of severe: T >38.5oC, or WCC >15, or rising creatinine or signs/symptoms of severe colitis.

1st episode:

metronidazole (MTZ)

 400mg TDS

10-14 days

2nd episode/severe/type 027:

oral vancomycin

 125mg QDS

10-14 days then taper

Recurrent: Discuss with microbiology