Protected Antibiotics - Permitted Indications

These antibiotics should ONLY be used for the indications listed below.

ALL OTHER USE MUST BE ON MICROBIOLOGY ADVICE ONLY

Ceftazidime

  • Febrile neutropenia (haematology and oncology patients only)
  • Exacerbations of bronchiectasis or cystic fibrosis (if Pseudomonas colonisation/infection and penicillin allergy)

Ceftriaxone

  • Only on advice of consultant clinician (except in meningitis) or microbiologist
  • Meningitis

Clindamycin

  • Streptococcal sepsis
  • Necrotising fasciitis or suspected necrotising fasciitis
  • Soft tissue infections in penicillin allergic patients only when benefits outweigh risk and no other option available; discuss with microbiology

Levofloxacin

  • As indicated in guideline in patients with true penicillin allergy
  • Strong clinical suspicion of Legionella infection

Linezolid

  • Only on advice of microbiologist

Meropenem - This may only be prescribed after consultation with senior member of clinical team

  • Exacerbation of bronchiectasis/cystic fibrosis if colonisation/infection with resistant Gram negative organisms including Pseudomonas
  • Febrile neutropenia (haematology/oncology patients)
  • Infections with multi resistant Gram negative bacilli
  • Severe sepsis unresponsive to Piperacillin/Tazobactam and Gentamicin

Teicoplanin

  • Vancomycin intolerance
  • Surgical prophylaxis (penicillin allergy or MRSA positive patients)
  • Out-patient and/or home parenteral antibiotic therapy

Temocillin

  • As indicated in the guidelines or after discussion with microbiologist

Tigecycline

  • Only on advice of microbiologist