Prosthetic Heart Valve Endocarditis

First Line

Vancomycin IV as per protocol AND Gentamicin 1mg/kg IV 12 hourly (synergistic dose) AND Rifampicin 600mg PO BD

Reduce dose of rifampicin to 300mg bd if severe renal impairment.  If oral route for rifampicin not available then use same dose IV.