IV Flucloxacillin 2g 6 hourly + / - IV Gentamicin
Allergy: or previous MRSA Positive IV : Vancomycin + IV Gentamicin
If at high risk of gram-negative sepsis (elderly frail, recurrent UTI,and recent abdominal surgery) Seek Microbiology advice within 48 hours
Tissue culture and blood culture very important
Seek specialist advice
Joint aspirate culture and blood culture very important. Antibiotics to be adjusted depending on results. Consider MRSA status.