Sepsis in Neutropenic Patients

First Line

Piperacillin / Tazobactam IV 4.5g 6 hourly

+

Gentamicin IV (Extended interval dosing as per guideline. Use gentamicin calculator).

DO NOT GIVE GENTAMICIN TO PATIENTS RECEIVING CISPLATIN CHEMOTHERAPY.

 

and see full Neutropenic Sepsis Pathway.

Penicillin Allergy

If non-severe Penicillin allergy (eg rash) Ceftazidime IV 2g eight hourly

+

Gentamicin IV (extended interval dosing as per guideline. Use gentamicin calculator)

DO NOT GIVE GENTAMICIN TO PATIENTS RECEIVING CISPLATIN CHEMOTHERAPY

 

If severe penicillin reaction, eg anaphylaxis.

Vancomycin IV (Dosing as per guideline. Use Vancomycin calculator)

+

Metronidazole IV 500mg eight hourly

+

Ciprofloxacin oral 750 mg twelve hourly

 

and see full Neutropenic Sepsis Pathway.

Notes

See neutropenic sepsis pathway for full guidelines.